NAD+ — nicotinamide adenine dinucleotide — is a coenzyme found in every cell of the body. It is essential for energy metabolism, DNA repair, and the regulation of cellular aging processes. Its decline with age is well-documented and has made it a significant target in longevity research.

What NAD+ Does

NAD+ functions as an electron carrier in the mitochondrial energy production process. It is also a substrate for sirtuins — proteins involved in DNA repair, gene expression regulation, and cellular stress response. Higher NAD+ availability is associated with improved mitochondrial function and cellular resilience.

Why It Declines

NAD+ levels decline significantly with age — by some estimates, dropping by more than 50% between early adulthood and midlife. This decline is accelerated by chronic inflammation, poor sleep, alcohol consumption, and metabolic dysfunction.

How NAD+ Is Administered

NAD+ can be supported through oral precursors such as NMN (nicotinamide mononucleotide) or NR (nicotinamide riboside). Intravenous NAD+ infusions deliver the coenzyme directly into the bloodstream for more immediate cellular availability.

IV NAD+ is used in our practice for patients focused on cognitive performance, cellular recovery, and metabolic optimization. It is also used in some addiction recovery protocols due to its effects on neurotransmitter restoration.

Who It Is Appropriate For

Patients with documented fatigue unresponsive to other interventions, those pursuing active longevity protocols, and individuals recovering from significant physiological stress are the most likely to benefit. As with all therapies we offer, we evaluate candidacy through labs and a thorough consultation before recommending it.